Regulation of synaptic vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUNDC3A, ATP8A1, and CDKL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle exocytosis activity versus RUNDC3A in GBM (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RUNDC3A →	+1.441	+0.998	<.001	<.001	3	4
GBM	ATP8A1 →	+1.101	+0.676	<.001	<.001	3	4
GBM	CDKL2 →	+0.878	+0.887	<.001	<.001	3	4
GBM	TMEM125 →	+1.267	+0.692	<.001	<.001	3	4
LSCC	SFTA1P →	+0.806	+0.441	<.001	<.001	3	4
GBM	HS3ST2 →	+1.151	+0.713	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000300 vs RUNDC3A — GBM

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