Regulation of synaptic vesicle exocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM160B1, KATNAL1, and PRKAG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM160B1 grouped by Regulation of synaptic vesicle exocytosis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FAM160B1 →	-1.093	-1.109	.001	.005	3	4
CNS	KATNAL1 →	-0.760	-1.081	.005	<.001	3	3
CNS	PRKAG2 →	-1.340	-1.003	.001	<.001	3	3
CNS	BCL2L1 →	-0.777	-0.852	.007	.007	3	3
CNS	CLTB →	-0.724	-1.000	<.001	.001	3	3
KIDNEY	HPS1 →	-0.683	-1.219	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM160B1 by Regulation of synaptic vesicle exocytosis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →