Regulation of synaptic vesicle exocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMR1, CHAC1, and TNPO3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle exocytosis activity versus FMR1 in LARGE_INTESTINE (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMR1 →	+1.060	+0.355	<.001	.003	3	6
LUNG_NSCLC_LUSC	CHAC1 →	-3.317	-0.745	.003	.001	3	4
OVARY	TNPO3 →	-0.569	-0.374	.007	.002	3	4
OVARY	PLPP3 →	+2.800	+0.463	.002	<.001	3	4
PANCREAS	BMP7 →	-3.607	-0.497	<.001	<.001	3	4
OVARY	HSPD1 →	-0.637	-0.398	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000300 vs FMR1 — LARGE_INTESTINE

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