Negative regulation of DNA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HROB, RFWD3, and DNMT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA biosynthetic process activity versus HROB in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HROB →	+0.532	+0.162	.002	.001	3	4
GBM	RFWD3 →	+0.499	+0.151	<.001	<.001	3	4
GBM	DNMT1 →	+0.406	+0.135	.004	.001	3	4
GBM	FANCA →	+0.573	+0.115	.006	.004	3	4
UCEC	ORC6 →	+0.512	+0.178	.002	<.001	3	4
CCRCC	ACTG1P14 →	+0.347	+0.220	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000279 vs HROB — GBM

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