Negative regulation of DNA biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABL1, NFATC4, and SNAI1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABL1 grouped by Negative regulation of DNA biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ABL1 →	+0.776	+0.191	.007	.006	3	5
SOFT_TISSUE	NFATC4 →	-3.069	-0.227	.001	.008	1	6
LUNG_NSCLC_LUAD	SNAI1 →	+1.306	+0.157	<.001	.001	3	4
BREAST	LRRCC1 →	-1.123	-0.118	<.001	.003	3	4
BREAST	FBXL22 →	-0.545	-0.157	.007	.008	3	4
LUNG_SCLC	ALOX12B →	-0.822	-0.220	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABL1 by Negative regulation of DNA biosynthetic process activity — KIDNEY

Explore this box plot interactively →