Negative regulation of DNA biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL37, TAF4B, and GEMIN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA biosynthetic process activity versus MRPL37 in PANCREAS (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRPL37 →	-0.667	-0.197	.009	.003	3	5
LUNG_SCLC	TAF4B →	-1.670	-0.162	<.001	<.001	3	5
PANCREAS	GEMIN5 →	-1.037	-0.235	.005	.007	3	5
OVARY	FAM81A →	-1.150	-0.100	.002	.002	3	5
BREAST	ABI2 →	-0.946	-0.115	.005	.004	3	4
BLOOD_Lymphoma	HHAT →	+1.310	+0.117	.003	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000279 vs MRPL37 — PANCREAS

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