Regulation of DNA biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TICAM2, PIK3CA, and PARVA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TICAM2 grouped by Regulation of DNA biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TICAM2 →	+0.861	+0.100	<.001	<.001	3	5
KIDNEY	PIK3CA →	+0.778	+0.248	.005	.004	3	5
LUNG_NSCLC_LUSC	PARVA →	+2.388	+0.202	.002	<.001	3	4
BREAST	ANKMY2 →	+0.708	+0.094	<.001	<.001	3	4
BREAST	TWSG1 →	+0.971	+0.104	.004	.003	3	4
BREAST	LCAT →	+0.983	+0.140	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TICAM2 by Regulation of DNA biosynthetic process activity — BREAST

Explore this box plot interactively →