Negative regulation of signaling receptor activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of signaling receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIVEP2, EPAS1, and PHACTR2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of signaling receptor activity activity versus HIVEP2 in DLBC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	HIVEP2 →	+1.422	+0.064	<.001	.001	3	28
THYM	EPAS1 →	+1.425	+0.039	<.001	<.001	3	28
CHOL	PHACTR2 →	+1.243	+0.046	<.001	.001	3	28
CHOL	EFCAB14 →	+1.043	+0.050	<.001	<.001	3	27
DLBC	PRKCH →	+2.007	+0.067	<.001	.001	3	27
DLBC	LCP2 →	+1.701	+0.058	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000272 vs HIVEP2 — DLBC

Explore this scatter interactively →