Negative regulation of signaling receptor activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of signaling receptor activity pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, HRH1, and KDELR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Negative regulation of signaling receptor activity-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TEAD1 →	+0.533	+0.116	.001	.001	3	5
BONE	HRH1 →	-0.194	-0.174	.008	.001	3	5
SKIN	KDELR1 →	-0.157	-0.062	<.001	.006	3	5
BONE	SLC10A3 →	-0.238	-0.181	.004	<.001	3	4
BLOOD_Leukemia	MYCN →	+0.188	+0.088	<.001	<.001	3	4
BLOOD_Leukemia	BAZ1A →	+0.172	+0.090	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Negative regulation of signaling receptor activity activity — STOMACH

Explore this box plot interactively →