Negative regulation of signaling receptor activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of signaling receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5A, TMEM265, and ADGRF1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of signaling receptor activity activity versus GPRC5A in LUNG_NSCLC_LUSC (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GPRC5A →	+4.824	+1.927	.001	<.001	3	11
OESOPHAGUS	TMEM265 →	+2.494	+1.282	.001	.001	3	7
OESOPHAGUS	ADGRF1 →	+2.915	+1.219	.005	.002	3	6
OESOPHAGUS	MST1R →	+1.990	+1.150	.009	.004	3	6
LUNG_NSCLC_LUAD	KRT19 →	+4.080	+1.022	.003	<.001	3	6
KIDNEY	PRAG1 →	+1.697	+1.630	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000272 vs GPRC5A — LUNG_NSCLC_LUSC

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