Positive regulation of feeding behavior

Across TCGA patient cohorts, RNA activity of the Positive regulation of feeding behavior pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX6, TRMT2A, and ABI3BP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of feeding behavior activity versus SNX6 in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNX6 →	+0.221	+0.055	<.001	.003	3	5
HNSC	TRMT2A →	-0.133	-0.046	.009	.005	3	5
HNSC	ABI3BP →	+0.767	+0.065	.004	.005	3	5
CCRCC	CD248 →	+0.255	+0.047	.003	<.001	3	5
LSCC	COL6A3 →	+0.412	+0.055	.001	.004	3	5
GBM	SP100_S171 →	+0.791	+0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000253 vs SNX6 — GBM

Explore this scatter interactively →