Negative regulation of feeding behavior

Across TCGA patient cohorts, RNA activity of the Negative regulation of feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL14EPP1, NFIL3, and EEF1A2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of feeding behavior activity versus ARL14EPP1 in PDAC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ARL14EPP1 →	+0.296	+0.137	.009	.002	3	2
GBM	NFIL3 →	+1.261	+0.273	.007	.008	3	2
PDAC	EEF1A2 →	-0.710	-0.133	.005	.003	3	1
PDAC	CYP2C18 →	-0.921	-0.115	.001	.006	3	1
PDAC	OTOF →	+0.145	+0.126	.008	.005	2	2
PDAC	GDPD2 →	-0.879	-0.172	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000252 vs ARL14EPP1 — PDAC

Explore this scatter interactively →