Negative regulation of feeding behavior

Across TCGA cell cohorts, RNA activity of the Negative regulation of feeding behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR4A2, VPS26C, and SUSD5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NR4A2 grouped by Negative regulation of feeding behavior-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NR4A2 →	+0.104	+1.155	.007	<.001	3	4
SKIN	VPS26C →	-0.233	-1.126	<.001	.002	3	4
KIDNEY	SUSD5 →	+0.225	+2.013	.006	<.001	3	4
SOFT_TISSUE	TLR10 →	-0.201	-1.346	.001	<.001	3	4
SKIN	TBX3 →	-0.182	-1.143	<.001	<.001	3	4
SKIN	ADAMTS4 →	-0.196	-1.262	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NR4A2 by Negative regulation of feeding behavior activity — BLOOD_Leukemia

Explore this box plot interactively →