Negative regulation of reproductive process

Across TCGA cell cohorts, RNA activity of the Negative regulation of reproductive process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDP, C2orf49, and OAS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDP grouped by Negative regulation of reproductive process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NDP →	+0.063	+0.354	.006	.006	3	3
SKIN	C2orf49 →	+0.483	+0.262	<.001	<.001	3	3
SKIN	OAS1 →	+1.879	+0.291	.005	.001	2	4
KIDNEY	FAM83H →	+1.205	+1.083	.006	.004	3	3
LIVER	UNC119 →	-0.788	-0.290	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	CLEC4A →	-0.436	-0.287	.009	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDP by Negative regulation of reproductive process activity — BLOOD_Lymphoma

Explore this box plot interactively →