Regulation of reproductive process

Across TCGA cell cohorts, RNA activity of the Regulation of reproductive process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNB1, CDCA8, and SPC25, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of reproductive process activity versus CCNB1 in STOMACH (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CCNB1 →	+1.085	+0.070	<.001	<.001	3	17
BREAST	CDCA8 →	+0.963	+0.051	<.001	<.001	3	17
OESOPHAGUS	SPC25 →	+1.233	+0.086	.001	<.001	3	17
OESOPHAGUS	BUB1 →	+1.028	+0.077	.006	<.001	3	17
BONE	AURKB →	+1.308	+0.073	<.001	<.001	3	17
STOMACH	CDCA3 →	+1.568	+0.092	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000241 vs CCNB1 — STOMACH

Explore this scatter interactively →