Regulation of reproductive process

Across TCGA cell cohorts, RNA activity of the Regulation of reproductive process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCK2, LSM12, and PMPCA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of reproductive process activity versus UCK2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	UCK2 →	-0.988	-0.379	<.001	.003	3	6
PANCREAS	LSM12 →	-0.931	-0.475	.001	<.001	3	6
PANCREAS	PMPCA →	-1.041	-0.479	.002	<.001	3	6
BLOOD_Myeloma	PRKACA →	-0.919	-0.400	.005	<.001	3	6
SKIN	FBL →	-0.596	-0.204	.003	.005	3	5
URINARY_TRACT	TAF4B →	-0.996	-0.376	.003	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000241 vs UCK2 — UPPER_AERODIGESTIVE_TRACT

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