Positive regulation of rRNA processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of rRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNE, PLEKHH1, and MTAP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFNE grouped by Positive regulation of rRNA processing-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IFNE →	-0.755	-0.253	.002	.004	3	5
LUNG_NSCLC_LUSC	PLEKHH1 →	+1.948	+0.238	.005	.003	3	4
PANCREAS	MTAP →	-4.348	-0.241	<.001	.001	2	5
OESOPHAGUS	RAB15 →	+1.794	+0.190	.004	.009	3	4
OESOPHAGUS	HIF1AN →	+0.838	+0.200	.004	.005	3	4
UPPER_AERODIGESTIVE_TRACT	PDCD2 →	+0.896	+0.197	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFNE by Positive regulation of rRNA processing activity — CNS

Explore this box plot interactively →