Positive regulation of rRNA processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of rRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GEMIN5, WDR75, and WDCP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of rRNA processing activity versus GEMIN5 in SKIN (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GEMIN5 →	+0.711	+0.822	.005	.006	2	6
URINARY_TRACT	WDR75 →	+0.626	+0.971	.006	.009	3	5
URINARY_TRACT	WDCP →	+0.701	+1.028	<.001	.004	3	5
URINARY_TRACT	PUS7 →	+0.658	+1.047	.008	.003	3	5
BREAST	EIF3I →	+1.043	+1.028	<.001	.001	3	5
BREAST	GEMIN6 →	+0.441	+0.640	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000234 vs GEMIN5 — SKIN

Explore this scatter interactively →