Regulation of rRNA processing

Across TCGA cell cohorts, RNA activity of the Regulation of rRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNE, NAA25, and ACTR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFNE grouped by Regulation of rRNA processing-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IFNE →	-0.874	-0.293	.002	.002	3	4
SOFT_TISSUE	NAA25 →	+0.622	+0.213	.005	.006	3	4
SOFT_TISSUE	ACTR3 →	+0.730	+0.179	.005	.004	2	5
SOFT_TISSUE	POLR1B →	+0.693	+0.228	.001	<.001	3	4
PANCREAS	MTAP →	-4.093	-0.259	<.001	.001	2	5
CNS	RPLP0 →	+0.627	+0.342	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFNE by Regulation of rRNA processing activity — CNS

Explore this box plot interactively →