Regulation of rRNA processing

Across TCGA cell cohorts, RNA activity of the Regulation of rRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM3, SAAL1, and NASP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of rRNA processing activity versus NPM3 in BREAST (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NPM3 →	+1.039	+0.780	<.001	<.001	3	7
BREAST	SAAL1 →	+0.938	+1.139	.001	<.001	3	6
SOFT_TISSUE	NASP →	+0.968	+0.806	.009	.007	3	6
BREAST	LYAR →	+1.342	+0.856	<.001	.004	3	6
BREAST	SF3A3 →	+0.650	+1.070	.006	<.001	3	6
OESOPHAGUS	PI4KA →	-1.383	-0.915	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000232 vs NPM3 — BREAST

Explore this scatter interactively →