Regulation of testosterone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of testosterone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HP1BP3, BSDC1, and KLHL42, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HP1BP3 grouped by Regulation of testosterone biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HP1BP3 →	-0.719	-1.095	<.001	.003	3	4
STOMACH	BSDC1 →	-1.065	-2.036	<.001	<.001	3	4
BLOOD_Lymphoma	KLHL42 →	-1.023	-2.067	.002	.001	3	4
BLOOD_Leukemia	SLAIN1 →	-2.692	-0.995	<.001	.008	3	3
BLOOD_Leukemia	TNFRSF10C →	+1.134	+0.892	.003	.002	3	3
LUNG_NSCLC_LUAD	TMEM150C →	-0.713	-0.663	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HP1BP3 by Regulation of testosterone biosynthetic process activity — STOMACH

Explore this box plot interactively →