Regulation of testosterone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of testosterone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C3, AKR1C1, and AKR1C2, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of testosterone biosynthetic process activity versus AKR1C3 in LUNG_NSCLC_LUSC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AKR1C3 →	+6.076	+0.255	<.001	<.001	3	17
LUNG_NSCLC_LUSC	AKR1C1 →	+6.266	+0.254	<.001	.001	3	14
LUNG_NSCLC_LUSC	AKR1C2 →	+7.377	+0.255	<.001	.004	3	12
LUNG_NSCLC_LUSC	ABHD2 →	+1.705	+0.272	.003	.001	3	10
UPPER_AERODIGESTIVE_TRACT	TRIM16L →	+1.575	+0.234	<.001	<.001	2	9
UPPER_AERODIGESTIVE_TRACT	CREB1 →	+1.201	+0.249	.002	.003	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000224 vs AKR1C3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →