Regulation of testosterone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of testosterone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNC, TIMM50, and PPP5C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of testosterone biosynthetic process activity versus SYNC in STOMACH (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SYNC →	-3.010	-2.169	<.001	<.001	3	3
OESOPHAGUS	TIMM50 →	+0.713	+2.000	<.001	<.001	3	3
OESOPHAGUS	PPP5C →	+0.553	+1.625	.009	.001	3	3
LIVER	CDKL1 →	+1.355	+1.968	.008	<.001	3	3
LIVER	FGFRL1 →	-1.215	-1.968	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ZNFX1 →	-0.746	-1.358	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000224 vs SYNC — STOMACH

Explore this scatter interactively →