Positive regulation of anoikis

Across TCGA patient cohorts, RNA activity of the Positive regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HASPIN, RANP1, and APBB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of anoikis activity versus HASPIN in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HASPIN →	+0.599	+0.472	<.001	<.001	3	5
BRCA	RANP1 →	+0.737	+0.390	.008	.001	3	5
BRCA	APBB1 →	-0.666	-0.458	.002	<.001	3	5
LSCC	TNS3 →	-0.755	-0.194	<.001	.001	3	4
BRCA	LMOD1 →	-0.867	-0.490	<.001	<.001	3	4
HNSC	FBP1 →	-1.038	-0.265	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000210 vs HASPIN — BRCA

Explore this scatter interactively →