Positive regulation of anoikis

Across TCGA cell cohorts, RNA activity of the Positive regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKACB, RNF103, and KAT2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKACB grouped by Positive regulation of anoikis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRKACB →	-1.520	-0.229	.001	.007	3	4
SOFT_TISSUE	RNF103 →	-0.847	-0.226	.006	.002	2	4
LUNG_NSCLC_LUSC	KAT2B →	-1.346	-0.914	<.001	.001	3	3
LUNG_NSCLC_LUAD	HECW2 →	+0.824	+0.667	.002	.002	3	3
BLOOD_Leukemia	ZNF227 →	-0.716	-0.216	<.001	.007	3	3
BLOOD_Leukemia	KLRG1 →	-1.548	-0.242	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKACB by Positive regulation of anoikis activity — BLOOD_Leukemia

Explore this box plot interactively →