Positive regulation of anoikis

Across TCGA cell cohorts, RNA activity of the Positive regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD1, PTRH2, and TAPT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of anoikis activity versus SMAD1 in BREAST (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMAD1 →	-0.956	-0.825	.002	.007	3	5
LUNG_NSCLC_LUAD	PTRH2 →	+0.831	+0.225	.006	.006	2	6
LUNG_SCLC	TAPT1 →	-1.186	-0.950	<.001	.003	3	5
BLOOD_Lymphoma	C21orf58 →	-1.151	-0.754	.005	.008	3	5
LUNG_SCLC	RPL13A →	+0.801	+0.886	.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	EDC3 →	-0.851	-0.264	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000210 vs SMAD1 — BREAST

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