Regulation of anoikis

Across TCGA cell cohorts, RNA activity of the Regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IPO4, CEP104, and GRWD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IPO4 grouped by Regulation of anoikis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IPO4 →	+0.982	+1.328	.001	.001	3	4
PANCREAS	CEP104 →	-0.806	-1.125	<.001	.006	3	4
LUNG_SCLC	GRWD1 →	+0.766	+1.326	<.001	.001	3	3
SOFT_TISSUE	WDR81 →	-0.838	-1.374	<.001	.001	3	3
LUNG_NSCLC_LUAD	INPP5K →	-0.433	-0.617	.004	.001	3	3
LUNG_NSCLC_LUAD	VPS51 →	-0.736	-0.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IPO4 by Regulation of anoikis activity — LUNG_SCLC

Explore this box plot interactively →