Regulation of anoikis

Across TCGA cell cohorts, RNA activity of the Regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAV3, RRAGD, and IMPA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of anoikis activity versus NAV3 in LUNG_NSCLC_LUSC (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NAV3 →	+2.553	+0.505	.002	.002	3	7
BONE	RRAGD →	-2.503	-0.316	<.001	.001	3	6
SOFT_TISSUE	IMPA2 →	-2.648	-0.479	.001	.002	3	6
STOMACH	ARHGAP44 →	-1.316	-0.251	.003	.002	3	6
LARGE_INTESTINE	PAXIP1 →	-0.611	-0.301	.005	.006	3	6
BLOOD_Lymphoma	BMP7 →	-3.231	-1.018	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000209 vs NAV3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →