Regulation of female gonad development

Across TCGA patient cohorts, RNA activity of the Regulation of female gonad development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAI14, LMCD1, and FERMT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of female gonad development activity versus RAI14 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAI14 →	+0.497	+0.112	<.001	.002	3	7
OV	LMCD1 →	+0.663	+0.061	<.001	.001	3	6
UCEC	FERMT2 →	+0.645	+0.114	<.001	<.001	3	6
UCEC	RSU1 →	+0.460	+0.099	<.001	.003	3	6
UCEC	FLNA →	+0.847	+0.130	<.001	<.001	3	6
UCEC	PARVA →	+0.498	+0.100	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000194 vs RAI14 — UCEC

Explore this scatter interactively →