Regulation of female gonad development

Across TCGA cell cohorts, RNA activity of the Regulation of female gonad development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADORA2B, PPM1M, and GLIPR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADORA2B grouped by Regulation of female gonad development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ADORA2B →	-2.261	-1.530	.002	<.001	3	5
BLOOD_Leukemia	PPM1M →	+1.770	+1.529	.003	.001	3	4
BONE	GLIPR1 →	-3.551	-1.233	.009	.003	3	4
BONE	NRP1 →	-2.897	-1.155	.002	<.001	3	4
CNS	ALAS1 →	-0.504	-0.696	.003	.009	2	5
BLOOD_Myeloma	AMPD3 →	+1.067	+1.282	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADORA2B by Regulation of female gonad development activity — BONE

Explore this box plot interactively →