Regulation of female gonad development

Across TCGA cell cohorts, RNA activity of the Regulation of female gonad development pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLL, IQCE, and ZZZ3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLL grouped by Regulation of female gonad development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	POLL →	+0.201	+1.391	.005	.004	3	3
SKIN	IQCE →	-0.132	-0.145	.004	.001	3	3
SKIN	ZZZ3 →	-0.140	-0.096	.001	.001	3	3
BONE	ASIC2 →	-0.292	-0.193	.003	.008	2	4
OVARY	SOS1 →	-0.350	-0.918	<.001	.005	3	3
OVARY	SMARCA5 →	+0.406	+1.117	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLL by Regulation of female gonad development activity — LIVER

Explore this box plot interactively →