Positive regulation of fatty acid transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of fatty acid transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD320, DET1, and MAP3K1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid transport activity versus CD320 in OESOPHAGUS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CD320 →	+1.670	+0.372	.006	.007	3	4
BLOOD_Leukemia	DET1 →	+0.729	+0.111	.003	.002	3	4
BLOOD_Lymphoma	MAP3K1 →	+1.174	+0.142	.008	<.001	3	4
LUNG_SCLC	PNN →	+1.157	+0.219	.001	.001	3	4
KIDNEY	RRAGD →	+1.662	+0.211	.002	.003	3	4
KIDNEY	WIPI1 →	-1.405	-0.172	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000193 vs CD320 — OESOPHAGUS

Explore this scatter interactively →