Regulation of fatty acid transport

Across TCGA patient cohorts, RNA activity of the Regulation of fatty acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRFBP1_S203, PLA2G4A, and DNMT1_S154, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid transport activity versus SRFBP1_S203 in LSCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRFBP1_S203 →	-0.518	-0.058	.006	<.001	3	6
LUAD	PLA2G4A →	+0.885	+0.043	<.001	<.001	3	6
GBM	DNMT1_S154 →	-0.960	-0.102	.001	<.001	3	5
GBM	MYO1G →	+0.696	+0.091	<.001	<.001	3	5
GBM	ARHGAP25 →	+0.465	+0.074	<.001	<.001	3	5
GBM	RAB27A →	+0.648	+0.076	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000191 vs SRFBP1_S203 — LSCC

Explore this scatter interactively →