Regulation of fatty acid transport

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid transport pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR2T27, ZNF513, and ADRM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR2T27 grouped by Regulation of fatty acid transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR2T27 →	-0.226	-0.120	.005	.008	3	4
STOMACH	ZNF513 →	-0.177	-0.142	.003	.007	3	4
OESOPHAGUS	ADRM1 →	+0.152	+0.111	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NUP155 →	+0.584	+0.153	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	AFG3L2 →	+0.423	+0.127	.003	<.001	3	4
BONE	SUDS3 →	+0.309	+0.169	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR2T27 by Regulation of fatty acid transport activity — KIDNEY

Explore this box plot interactively →