Regulation of fatty acid transport

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FIS1, ARFGEF1, and ZNHIT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid transport activity versus FIS1 in LUNG_NSCLC_LUSC (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FIS1 →	+1.029	+0.366	.002	.004	3	6
SOFT_TISSUE	ARFGEF1 →	+0.616	+0.274	.002	.005	3	5
LUNG_NSCLC_LUSC	ZNHIT1 →	+1.429	+0.518	.008	.003	3	5
LUNG_NSCLC_LUAD	POLR2J →	+0.442	+0.216	.001	<.001	3	5
LUNG_SCLC	PDGFC →	+2.937	+0.300	.001	<.001	3	4
LIVER	TMEM259 →	-0.845	-0.339	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000191 vs FIS1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →