Positive regulation of neural precursor cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of neural precursor cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNA, CAVIN3, and CAV1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neural precursor cell proliferation activity versus FLNA in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FLNA →	+1.960	+0.256	.009	.009	3	8
BREAST	CAVIN3 →	+3.012	+0.230	<.001	.002	3	7
LUNG_NSCLC_LUSC	CAV1 →	+4.415	+0.466	.007	<.001	2	7
LARGE_INTESTINE	MAP7D1 →	+1.176	+0.316	.003	<.001	3	6
BLOOD_Lymphoma	DEPTOR →	-3.041	-0.284	<.001	.001	3	5
BLOOD_Lymphoma	ARHGAP31 →	+1.320	+0.205	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000179 vs FLNA — LIVER

Explore this scatter interactively →