Negative regulation of neural precursor cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of neural precursor cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN14P21, BFSP2-AS1, and SCML4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neural precursor cell proliferation activity versus SEPTIN14P21 in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEPTIN14P21 →	+0.084	+0.654	.001	<.001	3	3
GBM	BFSP2-AS1 →	-0.163	-0.432	<.001	.007	3	3
HNSC	SCML4 →	-0.508	-0.606	.001	<.001	3	3
HNSC	RPS17P13 →	-0.601	-0.465	.004	.004	3	3
LUAD	IL26 →	-0.426	-0.408	.001	.005	3	3
LUAD	MTND2P9 →	-0.127	-0.416	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000178 vs SEPTIN14P21 — CCRCC

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