Regulation of neural precursor cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of neural precursor cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, QKI, and VCAN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neural precursor cell proliferation activity versus TLN2 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN2 →	+0.614	+0.024	<.001	<.001	3	8
HNSC	QKI →	+0.239	+0.051	<.001	<.001	3	8
OV	VCAN →	+1.152	+0.037	<.001	.002	3	7
LSCC	CNPY4 →	+0.414	+0.038	<.001	<.001	3	7
BRCA	VCL →	+0.447	+0.038	<.001	<.001	3	7
LSCC	FILIP1L →	+0.602	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000177 vs TLN2 — BRCA

Explore this scatter interactively →