Regulation of neural precursor cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of neural precursor cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCUN1D5, IGFBP6, and FLII, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neural precursor cell proliferation activity versus DCUN1D5 in BONE (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DCUN1D5 →	-1.216	-0.616	.002	<.001	3	5
LARGE_INTESTINE	IGFBP6 →	+3.734	+0.441	<.001	<.001	3	5
LARGE_INTESTINE	FLII →	+0.781	+0.423	.002	<.001	3	5
LUNG_NSCLC_LUAD	PDE3B →	-1.037	-0.302	.002	<.001	3	5
BREAST	CREG2 →	+0.708	+0.212	<.001	.003	3	5
LIVER	PDSS1 →	-1.252	-0.584	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000177 vs DCUN1D5 — BONE

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