Negative regulation of dendrite development

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendrite development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL11A, CHERP, and MED26, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendrite development activity versus BCL11A in LSCC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BCL11A →	+1.270	+1.251	<.001	<.001	3	6
LSCC	CHERP →	+0.492	+0.699	<.001	<.001	3	5
LSCC	MED26 →	+0.287	+0.687	<.001	<.001	3	5
HNSC	MIPEPP3 →	+0.744	+0.698	<.001	<.001	3	5
LSCC	CUX1 →	+0.540	+0.902	.009	<.001	2	6
HNSC	MAP3K14-AS1 →	+0.354	+0.588	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000171 vs BCL11A — LSCC

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