Negative regulation of dendrite development

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendrite development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCL11A_S608, BCL11A_S432, and BCL11A_S205, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendrite development activity versus BCL11A_S608 in LSCC (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BCL11A_S608 →	+1.498	+1.773	<.001	<.001	3	5
LSCC	BCL11A_S432 →	+1.463	+1.360	<.001	<.001	3	5
LSCC	BCL11A_S205 →	+1.023	+1.115	<.001	<.001	3	4
HNSC	CRACD_S1017 →	+0.887	+1.422	<.001	<.001	3	4
LSCC	NUP88_T525 →	+0.683	+1.234	<.001	<.001	3	4
LSCC	DTWD1 →	+0.310	+0.791	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000171 vs BCL11A_S608 — LSCC

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