Negative regulation of dendrite development

Across TCGA cell cohorts, RNA activity of the Negative regulation of dendrite development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC14L2, FDX1, and DPH5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC14L2 grouped by Negative regulation of dendrite development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SEC14L2 →	-1.364	-1.349	.007	.004	3	4
LIVER	FDX1 →	+0.663	+1.398	.002	.001	3	4
LUNG_NSCLC_LUAD	DPH5 →	+0.587	+0.950	.009	.004	3	4
UPPER_AERODIGESTIVE_TRACT	KCNMA1 →	-2.599	-1.166	<.001	<.001	3	4
OVARY	KCNAB3 →	-0.856	-1.079	.005	.001	3	4
OVARY	ZNF808 →	-0.962	-1.197	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC14L2 by Negative regulation of dendrite development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →