Negative regulation of dendrite development

Across TCGA cell cohorts, RNA activity of the Negative regulation of dendrite development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMSAP3, IL17RD, and BICC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendrite development activity versus CAMSAP3 in BREAST (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CAMSAP3 →	-2.016	-1.052	.001	<.001	3	4
CNS	IL17RD →	+2.238	+1.493	.006	<.001	3	4
PANCREAS	BICC1 →	+4.176	+1.809	.008	.007	2	5
OVARY	AQP7 →	+0.170	+1.147	<.001	.006	3	4
LARGE_INTESTINE	TRIP10 →	+1.095	+1.109	.001	.003	3	4
BREAST	PHLDA1 →	+2.802	+1.066	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000171 vs CAMSAP3 — BREAST

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