Positive regulation of DNA-templated transcription initiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTPBP3, SLC25A42, and NEDD4L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTPBP3 grouped by Positive regulation of DNA-templated transcription initiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GTPBP3 →	-0.683	-0.239	.008	<.001	3	5
LUNG_NSCLC_LUSC	SLC25A42 →	-1.140	-0.247	.003	.006	3	5
LUNG_SCLC	NEDD4L →	+1.042	+0.183	.006	.004	3	4
BLOOD_Lymphoma	SH3RF1 →	-0.792	-0.285	.007	.002	3	4
LIVER	PDLIM1 →	-1.124	-0.193	.007	.007	3	4
LIVER	IQSEC1 →	-1.205	-0.189	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTPBP3 by Positive regulation of DNA-templated transcription initiation activity — LIVER

Explore this box plot interactively →