Positive regulation of DNA-templated transcription initiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HENMT1, TTLL12, and DNASE2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA-templated transcription initiation activity versus HENMT1 in OVARY (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HENMT1 →	-2.086	-1.130	<.001	<.001	3	5
LUNG_SCLC	TTLL12 →	+0.887	+0.605	<.001	.007	2	6
STOMACH	DNASE2 →	-1.182	-1.263	.009	.001	3	4
STOMACH	PRDM10 →	+0.768	+1.193	.002	.006	3	4
SOFT_TISSUE	CASP3 →	+0.710	+1.604	.004	.002	3	4
OVARY	SPATA5L1 →	+0.753	+1.245	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000144 vs HENMT1 — OVARY

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