Negative regulation of DNA-templated transcription initiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA-templated transcription initiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNFAIP8, DOK3, and MNDA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA-templated transcription initiation activity versus TNFAIP8 in UCEC (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TNFAIP8 →	-0.514	-0.097	<.001	<.001	3	6
UCEC	DOK3 →	-0.404	-0.079	.001	<.001	3	6
UCEC	MNDA →	-0.567	-0.097	.004	<.001	3	6
PDAC	NCF1_S348 →	-0.631	-0.043	<.001	<.001	3	6
CCRCC	NCF4 →	-0.440	-0.075	.003	<.001	3	6
CCRCC	NRBF2 →	-0.368	-0.061	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000143 vs TNFAIP8 — UCEC

Explore this scatter interactively →