Negative regulation of DNA-templated transcription initiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB9, TCERG1, and CENPH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA-templated transcription initiation activity versus ZBTB9 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZBTB9 →	+0.380	+0.094	.001	.004	3	5
LSCC	TCERG1 →	+0.355	+0.115	.004	.001	3	4
LSCC	CENPH →	+0.728	+0.125	<.001	<.001	3	4
LSCC	LINC02772 →	-0.336	-0.117	<.001	.004	3	3
LSCC	MCM3 →	+0.572	+0.086	.001	.003	3	3
UCEC	TMEM26 →	-0.884	-0.146	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000143 vs ZBTB9 — LSCC

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