Negative regulation of DNA-templated transcription initiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf35, APOBEC3C, and STX1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf35 grouped by Negative regulation of DNA-templated transcription initiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf35 →	+0.457	+0.194	<.001	<.001	3	4
LARGE_INTESTINE	APOBEC3C →	-2.420	-0.178	.002	.005	3	4
OESOPHAGUS	STX1A →	-1.178	-0.183	.005	.006	3	3
OESOPHAGUS	NFIL3 →	-0.880	-0.260	.003	.007	3	3
BLOOD_Leukemia	ALDH5A1 →	-1.090	-0.227	.003	.001	3	3
BLOOD_Leukemia	LHX4 →	-0.670	-0.213	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf35 by Negative regulation of DNA-templated transcription initiation activity — LARGE_INTESTINE

Explore this box plot interactively →