Regulation of DNA-templated transcription initiation

Across TCGA cell cohorts, RNA activity of the Regulation of DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM1, IL4R, and PFAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDLIM1 grouped by Regulation of DNA-templated transcription initiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PDLIM1 →	-3.247	-0.197	.008	.001	3	5
LUNG_SCLC	IL4R →	+1.959	+0.165	.002	.007	3	4
BLOOD_Leukemia	PFAS →	-0.967	-0.193	.003	.004	3	4
BLOOD_Leukemia	SUFU →	-1.083	-0.275	<.001	<.001	3	4
BLOOD_Leukemia	CD68 →	+2.377	+0.166	.006	.001	3	4
BLOOD_Leukemia	ARL3 →	-0.859	-0.177	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDLIM1 by Regulation of DNA-templated transcription initiation activity — BLOOD_Leukemia

Explore this box plot interactively →