Regulation of DNA-templated transcription initiation

Across TCGA cell cohorts, RNA activity of the Regulation of DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIGYF2, TTLL12, and UQCRB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated transcription initiation activity versus GIGYF2 in LUNG_NSCLC_LUSC (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GIGYF2 →	+1.203	+1.734	.005	<.001	3	5
OVARY	TTLL12 →	+1.163	+1.200	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	UQCRB →	+1.065	+0.918	.005	.009	3	4
URINARY_TRACT	ITFG2 →	+0.607	+1.754	.005	.002	3	4
URINARY_TRACT	SSB →	+0.750	+1.660	.002	<.001	3	4
URINARY_TRACT	CDCA7 →	+1.129	+1.660	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000142 vs GIGYF2 — LUNG_NSCLC_LUSC

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